Composition and Pharmacological Effect of the Extract of Domestic Crataegus Pinnatifida Bge. var. major N. E. Br.     In recent years ,the plant Research Institute of the Chinese Academy of Sciences, the Chemical Research Institute of the CAS, the Chinese University of Pharmacy, the Shanghai Research Institute of Medicinal Industries, Guangzhou Zhongshan University, Nanjing College of Traditional chinese Medicine, Hunan Medical College,Shandong Medical University,the Research Institute of Traditional Chinese Medicine of Shandong Province, the Drug Control Institute of Shandong Province, Shanxi Medical College, Jilin Agricultural University, Jilin Agricultural Academy of Sciences, and other colleges and universities, research departments and drug control institutes have made extensive and fairly thorough studies of the chemical composition or pharmacological effect of domestic Crataegus Pinnatifida Bge. var: major N. E. Br. ,and have extracted and then separated from the dried ripe fruit of Crataegus Pinnatifida Bge. var. major N. E. Br. flavonoid, triterpenes, tannin, linoleic acid,lemon tincture, malic acid, chlorogenic acid, carotin, vitamin C, vitamin BI, B2, trace elements and other ingredients. They have also carried out pharmacological research on the Fructus Crataegi extract. What follows is a list of the composition and pharmacological effects of the extract of domestic Crataegus Pinnatifida Bge. var. major N. E. Br. Composition Pharmacological Effect Flavoncid: Quercetin Hyperoside Epicatechin Flavan polyiners Lowers blood pressure, expands coronary blood vessels, increases 'coronary flow, raises the permeability of cardiac capillaries and myocardial fibers, increases the nutritional volume of blood flow of the myocardium; has a protective effect on experimental myocardiac infarction in rabbits and dogs ,and has the effect of preventing and alleviating experimental myocardial ischemia, hypoxia, and myocardial necrosis in hamsters, guinea pigs and rabbits ; has the explicit function of lowering the blood-lipidity of suckling and young hamsters and is effective in lowering the serum cholesterol and B-lipoprotein of rabbits afflicted with experimental hyperlipemia. Triterpenes: Ursolic acid Aleanolic acid Crataegolic acid Lowers blood-lipidity and blood pressure and resists atherosclerosis; can increase the volume of blood flow of the coronary blood vessels and improve coronary heart circulation so as to compensate for coronary arterial failure, strengthen the heart,raise the sensitivity of the rnyocardium to the action of cardiac glycoside, increase cardiac output ,and attenuate myocardial irritability and conductibility; has the function of resisting ventricular fibrillation,auricular fibrillation and paroxysmal arrhythmia; is also effective in restoring the pulse of an exhausted heart. Tannin Flavonoid tannin Can give rise to marked and long-term coronary arteriectasia in a guinea pig's heart;at the same time can enhance the amplitude of vibration of cardiac contraction ;can also increase the flow of the coronary artery of a dog's heart in vivo. The seeds of Domestic Crataegus Pinnatifida Bge. var. major N. E. Br.: Ursolic acid Aleanolic acid Quercetin Hyperoside linloeic acid Lowers the blood serum of a quail afflicted with hypercholesterolemia by Tc33. 7'-' 62. 8% and lowers (LDC+VLDC)-C by 34.4'--65.6%; can tangibly lower the ratio of Tc/HDL-C and decrease the sedimentation of cholesterol and cholesterol lipidity in the arterial parietes.; function increases with the increase of the dosage of the drug, indicating a preventive effect on atherosclerosis.